Thursday, February 27, 2014

Lessons from crocheting alcohol dehydrogenase

  1. The difficulty of folding up tertiary structure does NOT scale linearly with amino acid length. One monomer of alcohol dehydrogenase is 374 amino acids long. That's only about 3x as long as lysozyme, but I nearly lost my mind. 
  2. Bobby pins are essential for the folding process. Use them to keep beta sheets flat as you fold, and also to space helices apart from one another. 
  3. Hang the structure as you fold it. Especially important early in the process.
  4. Chainbows are wonderful :)
I'm planning on writing up full instructions of this process, and maybe even making a tutorial video (my first!) Stay tuned.



3 comments:

Seamstress Erin said...

amazingsauce.

Suvi said...

This is gorgeous! You have just inspired me to take my crocheting to the next level. Simply amazing.

~Sara said...

Wow. This is quite possibly the coolest blog I've ever come across. Your crochet skillzzz and attention to biologically accurate detail is delightful and inspiring. Thanks for being amazeballs...